The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression.

Like most introductory science textbooks, this one opens with a discussion of scientific method. A key feature is its focus on experimental support for what we know about cell and molecular biology. Understanding how science is practiced and how investigators think about experimental results is essential to understanding the relationship of cell structure and function…, not to mention our relationship to the natural world. This is a free Open Education Resource (OER), covered by a Creative Commons CCBY license (check out the Preface!). Every chapter begins with learning objectives and links to relevant recorded lectures. As used by the author, the iText engages students with embedded “just-in-time” learning tools. These include instructor’s annotations (comments) directing students to animations or text of interest, as well as links to writing assignments and quizzes. These interactive features aim to strengthen critical thinking and writing skills necessary to understand cell and molecular biology, not to mention science as a way of thinking in general. Please excuse the marketing terms, but you can choose between Bronze, Silver, or Gold versions, reflecting increasing potential for student interaction with the iText. Download your choice of the iText or the sample chapter at one of the links below.

Subject covers all major areas of cellular and molecular neurobiology including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell type determination, axon guidance and targeting, neuronal cell biology, synapse formation and plasticity. Includes lectures and exams, and involves presentation and discussion of primary literature. Focus on major concepts and recent advances in experimental neuroscience.

The endoplasmic reticulum (ER) orchestrates different cellular processes by which proteins are synthesized, correctly folded, modified and ultimately transported to their final destinations. As part of this crucial biosynthetic process, proteins that are not properly folded and consequently detrimental to normal cellular function are constantly generated. A common signature of many neurodegenerative diseases, including Alzheimer's and Parkinson's, is accumulation and deposition of misfolded proteins that arise when the ability of cells to deal with the burden of misfolded proteins is compromised. In this course, we will explore how the ER quality control machinery ensures that only properly assembled proteins exit the ER while distinguishing between nascent proteins en route to their biologically active folded state from those that are terminally misfolded.

This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.

Surveys the molecular and cellular mechanisms of neuronal communication. Covers ion channels in excitable membrane, synaptic transmission, and synaptic plasticity. Correlates the properties of ion channels and synaptic transmission with their physiological function such as learning and memory. Discusses the organizational principles for the formation of functional neural networks at synaptic and cellular levels.

Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of the case covering a number of immunological issues in the context of disease are posted on a student Web site.

In this lesson plan, students will learn the basic structure and function of DNA and RNA. They will also learn the process of gene expression. Finally, students will learn about the scientific contributor, Ernest Everest Just, and his contributions to the field of Biology.

Brief animation showing how a primary and secondary antibody are used to detect C-fos, an immediate early gene transcribed as a result of recent neural activity. To see why and how C-fos is made please watch the companion video Cfos neural activity

This animation shows how electrical impulses generated by neurons (action potentials) lead to the expression of C-fos by the cell nucleus. C-fos is thus considered an immediate early gene product of recent neural activity. It is widely used in neuroscience as a post-hoc readout of recently active neurons. To see how C-fos is detected experimentally for visualization and quantification please watch the companion video C-fos Immunolabeling.

This resource has been created for my students enrolled in my Fundamentals of Biology course at West Hills Community College in Lemoore, CA.

Introduces the design of chemical reactors via synthesis of chemical kinetics, transport phenomena, and mass and energy balances. Topics: reaction mechanisms and chemical/biochemical pathways; transition-state theory; batch, plug flow and well-stirred reactors; heterogeneous and enzymatic catalysis; heat and mass transport in reactors, including diffusion to and within catalyst particles and cells or immobilized enzymes.

This kit is a historical overview of American representations of chemicals from the three sisters to the Love Canal. It compares conflicting constructions about nuclear reactor safety, depleted uranium, Rachel Carson and DDT. Through analyzing diverse historic and contemporary media messages, students understand changing public knowledge, impressions and attitudes about chemicals in the environment.

This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making. Throughout the term, students consider case studies of local and national interest.

This seminar will focus on three sports: swimming, cycling and running. There will be two components to the seminar: classroom sessions and a "laboratory" in the form of a structured training program. The classroom component will introduce the students to the chemistry of their own biological system. With swimming, running and cycling as sample sports, students are encouraged to apply their knowledge to complete a triathlon shortly after the term.

One of the major components of the First Year Seminar in Natural Sciences (NSF101) is to introduce students to library research. The library orientation session exposes students to library resources such as books, videos, journals, databases. The "Choosing Your Career" assignment reinforces using the library by searching for information on a career, retrieving sources from select databases and evaluating the information found in a written reflection. Reflection questions are added to guide the student in their search and their approach to their career choice.
The goal is to integrate library literacy as part of their developing college learning skills. This assignment effectively introduces information literacy as the ability to find and use information and critically think about the information found when deciding on a career path.
This assignment consists of the following;
90-minute library orientation session (one lecture session)
followed up by library research (students' time)
initial draft (hard copy for instructor comments)
written revision (students' time)
a final written 1500-word research reflection. (deposited on student ePortfolio)
Objectives
1. Identify one science profession that interests you
2. Research the profession using library resources
3. Write a 1500-word reflection including the questions posed

This course is designed to provide an understanding of how the human brain works in health and disease, and is intended for both the Brain and Cognitive Science major and the non-Brain and Cognitive Science major. Knowledge of how the human brain works is important for all citizens, and the lessons to be learned have enormous implications for public policy makers and educators. The course will cover the regional anatomy of the brain and provide an introduction to the cellular function of neurons, synapses and neurotransmitters. Commonly used drugs that alter brain function can be understood through a knowledge of neurotransmitters. Along similar lines, common diseases that illustrate normal brain function will be discussed. Experimental animal studies that reveal how the brain works will be reviewed. Throughout the seminar we will discuss clinical cases from Dr. Byrne's experience that illustrate brain function; in addition, articles from the scientific literature will be discussed at each class.

Has your attention recently been caught by news of coastal catastrophes such as hurricanes and tsunamis? Do you wonder why so many coastal communities in the world are vulnerable to flooding and other coastal hazards? Have you considered what coastal flood protections cities like Houston and Miami will need in the future to protect their residents? This course will provide a better understanding of these phenomena. We present a global perspective of coastal landscapes, the geologic processes responsible for their formation, and ways that society responds to hazards like sea level rise and catastrophic weather events. You will participate in active learning exercises such as analyzing real-world datasets and applying critical thinking to real-world societal problems while investigating a coastal community.

Cocaine afflicts many individuals and is potently addictive. Originally hailed as a wonder-drug in the late 19th century, cocaine is now considered an illegal substance. Cocaine’s addictive properties can be attributed to changes in the dopamine reward pathway of the Ventral Tegmental Area and Substantia Nigra, Prefrontal Cortex, Dorsal Striatum, Nucleus Accumbens, Amygdala, Globus Pallidus, and Hippocampus. This drug affects the brain in two processes: binge and crave. The binge process highlights cocaine’s ability to block dopamine reuptake from the synapse resulting in hyperstimulation of the postsynaptic neuron in the dopamine reward pathway. The crave process promotes drug-seeking behavior through conditional and contextual cues. Understanding the effects of cocaine in the brain may grant insight in creating future medication and therapies to treat individuals addicted to this drug.

Cocaine afflicts many individuals and is potently addictive. Originally hailed as a wonder-drug in the late 19th century, cocaine is now considered an illegal substance. Cocaine’s addictive properties can be attributed to changes in the dopamine reward pathway of the Ventral Tegmental Area and Substantia Nigra, Prefrontal Cortex, Dorsal Striatum, Nucleus Accumbens, Amygdala, Globus Pallidus, and Hippocampus. This drug affects the brain in two processes: binge and crave. The binge process highlights cocaine’s ability to block dopamine reuptake from the synapse resulting in hyperstimulation of the postsynaptic neuron in the dopamine reward pathway. The crave process promotes drug-seeking behavior through conditional and contextual cues. Understanding the effects of cocaine in the brain may grant insight in creating future medication and therapies to treat individuals addicted to this drug.